'Activate on first use' is a subscription setting that allows your customers to pay for this subscription's initial billing cycle, then start their renewal cycle whenever they want to.
Things to know before toggling this on:
As soon as the customer registers for a class using the subscription, the subscription's renewal cycle will be scheduled to begin on the day of that class
If the customer then books another class for an earlier date, this will update their subscription's start date to the earlier class date
Do not use 'Activate on first use' if you want your customers to immediately start their renewal cycles after their first subscription purchase.